Diarrhea Diarrhea Was The Most Common Adverse Reaction Of Linzess-treated Patients In The Pooled Ibs-c And Cic Double-blind Placebo-controlled Trials.

Use of LINZESS should be avoided in pediatric patients 6 through 17 years of age. Although there were no deaths in older juvenile mice, given the deaths in young juvenile mice and the lack of clinical safety and efficacy data in pediatric patients, use of LINZESS should be avoided in pediatric patients 6 through 17 years of age. Diarrhea Diarrhea was the most common adverse reaction of LINZESS-treated patients in the pooled IBS-C and CIC double-blind placebo-controlled trials. Severe diarrhea was reported in 2% of LINZESS-treated patients. The incidence of diarrhea was similar in the IBS-C and CIC populations. Patients should be instructed to stop LINZESS if severe diarrhea occurs and to contact their healthcare provider. The healthcare provider should consider dose suspension and rehydration. Adverse Reactions In IBS-C clinical trials, the most common adverse reactions in LINZESS-treated patients (incidence 2% and greater than placebo) were diarrhea (20% vs 3% placebo), abdominal pain (7% vs 5%), flatulence (4% vs 2%), headache (4% vs 3%), viral gastroenteritis (3% vs 1%) and abdominal distension (2% vs 1%). In CIC clinical trials, the most common adverse reactions in LINZESS-treated patients (incidence 2% and greater than placebo) were diarrhea (16% vs 5% placebo), abdominal pain (7% vs 6%), flatulence (6% vs 5%), upper respiratory tract infection (5% vs 4%), sinusitis (3% vs 2%) and abdominal distension (3% vs 2%). Please see full Prescribing Information including Boxed Warning: http://www.frx.com/pi/linzess_pi.pdf .

For the original version including any supplementary images or video, visit http://finance.yahoo.com/news/ironwood-reports-positive-top-line-130000493.html

  • http://intelligenttravel.nationalgeographic.com/2014/07/14/the-world-in-a-cuppa-tea/
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So They Should Be Charged With A Crime Of Mis-education; Taking Taxpayers Money, But Not Appropriately Educating The Children.

Following the reign of a number of state-appointed emergency managers in the Detroit Public Schools, Kwame Kenyatta says the district is deeper in debt and standardizedtest scores are criminal proving the system is failing. Kenyatta, who is also an ex-elected Detroit school board member, told WWJs Vickie Thomas hed likesee a class action lawsuit filed against Michigan. To set up an experiment, like mice in a lab, this EAA (Education Achievement Authority) project, and then you see people whether theyre here on in Chicago former employees who have stolen millions of dollars out of the system and from the children. Kenyattas comments come twoweeksafter the 2015 National Assessment of Educational Progress exam results were released, showing just how poorly Detroit students are failing. Among the findings: 96 percent of DPS eighth graders are not proficient in math, and 93 percent not proficient in reading. A mere 6percent of Detroit fourth graders were proficient or above in reading, compared to about 36 percent nationally, and 29 percent in Michigan. Kenyatta said the state government should be held accountable for these failings. I believe that the state of Michigan should be suedI mean, I think its a crime, Kenyatta said. So they should be charged with a crime of mis-education; taking taxpayers money, but not appropriately educating the children. The Education Achievement Authorityof Michigan is a fairly new statewide school system that has assumed operation of the lowest 5 percent of performingschools in the state that did not achieve satisfactory results on a redesign plan or that are under an emergency manager. The always outspoken Kenyatta, who now lives in Mississippi, is in town this week to serve as keynote speaker at a State of Detroit forum.

For the original version including any supplementary images or video, visit http://detroit.cbslocal.com/2015/11/11/detroit-school-kids-treated-like-mice-in-a-lab-says-former-councilman-calling-for-lawsuit-against-state/

In Winter, Cold Weather, Blustery Winds And Frozen Soil Reduce Plants’ Ability To Absorb Much Needed Moisture To Maintain Vitality.

Instead, opt for a proven effective, all-natural topical spray repellent like Bobbex Deer Repellent . Available as a ready-to-use spray or concentrate, Bobbex’s taste and smell deterrent won’t wash off in rain or snow, and proved 93 percent effective in independent testing by the Connecticut Agricultural Experiment Station. Visit www.bobbex.com to learn more. Ridding yards of rodents If you’re a fall gardener, rabbits, squirrels, chipmunks and other herbivores can do more damage to your landscape than frost. Fencing and other types of deterrents like plastic owls often aren’t effective in scaring herbivores away. Bobbex-R Animal Repellent is an all-natural, topical spray that repels small herbivores but is harmless to all wildlife, people, pets and contains no petro chemicals. Rain, snow, hosing and irrigation won’t wash the product off, and you can even use it as a bulb-dip to prevent below-ground foraging. It can also be sprayed at the mouth of burrows and holes to prevent animal re-entry. Bobbex-Rwill also help protect plantings from reduced moisture content during periods of water reduced weather conditions. In winter, cold weather, blustery winds and frozen soil reduce plants’ ability to absorb much needed moisture to maintain vitality. Bobbex-R provides retention of moisture in plantings through periods of frigid weather, and reduces damage from early fall frost. Pro-Active Tips to keep critters out of homes Mice, rats and even raccoons can take up residence inside homes when the weather turns cold.

For the original version including any supplementary images or video, visit http://www.prnewswire.com/news-releases/cold-weather-and-critters-are-coming-bobbex-suggests-sensible-steps-to-keep-unwanted-animals-out-of-your-environment-300160597.html

  • http://gomexico.about.com/od/fooddrink/ss/what-to-eat_7.htm
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The Collaboration With The Startup Entity, Thrive Agrobiotics, Inc., Plans To Utilize Intrexon’s Actobiotics Platform To Express Nutritive Proteins For Improving The Overall Growth And Feed Efficiency In Piglets, Thereby Expanding The Application Of This Innovative Biologic Delivery Platform To Animals; Expanded Relationship With Ziopharm Oncology, Inc.

Dominion will be the exclusive partner to construct, own, operate, and maintain the production facilities in the Marcellus and Utica Shale Basins located in eastern North America via potential long-term services agreements with IEP; Established first Exclusive Channel Collaboration (ECC) with a startup backed by an investment fund that is dedicated to the inventions of Intrexon and sponsored by Harvest Capital Strategies, LLC. The collaboration with the startup entity, Thrive Agrobiotics, Inc., plans to utilize Intrexon’s ActoBiotics platform to express nutritive proteins for improving the overall growth and feed efficiency in piglets, thereby expanding the application of this innovative biologic delivery platform to animals; Expanded relationship with ZIOPHARM Oncology, Inc. ( ZIOP ) through an ECC for the treatment and prevention of graft-versus-host disease (GvHD), a major complication of allogeneic hematopoietic stem-cell transplantation that significantly impairs the quality of life and survival of many recipients. The collaboration will focus on addressing the underlying pathologies of GvHD through engineered cell platforms to express and deliver interleukin-2 (IL-2), a cytokine critical for modulation of the immune system; Entered into an ECC with Synthetic Biologics, Inc. (NYSE MKT: SYN) to pursue the development and commercialization of novel biotherapeutics for the treatment of patients with phenylketonuria (PKU), a serious and debilitating metabolic disorder. The collaboration aims to target delivery of an essential enzyme via Intrexon’s ActoBiotics platform without having an adverse impact on the gut microbiome; With collaborator Fibrocell Science, Inc. ( FCSC ) provided an update on the status of the Investigational New Drug (IND) application for FCX-007, Fibrocell’s orphan gene-therapy drug candidate for the treatment of the skin disorder recessive dystrophic epidermolysis bullosa (RDEB). At the request of the U.S. Food and Drug Administration (FDA), Fibrocell will conduct an additional toxicology-specific study and expects to amend the IND in response to the FDA’s feedback, including data from the new toxicology study, in the first quarter of 2016; Through wholly owned ViaGen Pets, announced successful feline cloning for customers and plans to launch broadly available companion animal service and product offering in 2016; Announced key management additions of Corey Huck as SVP, Head of Food Sector, and Joseph L. Vaillancourt, SVP, Head of Environment Sector; and Completed a public offering of common stock resulting in total gross proceeds of approximately $230 million, before deducting the underwriting discounts, commissions, and estimated expenses. Third Quarter Financial Highlights: Total revenues of $53.4 million, an increase of 152% over the third quarter of 2014; Net loss of $38.2 million attributable to Intrexon, or $(0.34) per basic share; Adjusted EBITDA of $3.8 million, or $0.03 per basic share; Cash consideration received for reimbursement of research and development services covered 59% of cash operating expenses (exclusive of operating expenses of consolidated subsidiaries); and Cash, cash equivalents, and short-term and long-term investments totaled $352.6 million, and the value of equity securities totaled $76.6 million at September 30, 2015.

For the original version including any supplementary images or video, visit http://finance.yahoo.com/news/intrexon-announces-third-quarter-2015-210500056.html

  • http://www.foxnews.com/world/2014/06/07/petro-poroshenko-new-ukraine-president-sworn-into-office/
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Food And Drug Administration For Use As Cancer Treatment Or Any Other Medical Condition, According To Nci.

“We can have an intellectually honest debate about whether we should legalize something that is bad and dangerous, but don’t call it medicinethat is a joke.” Currently, 23 states and the District of Columbia have laws legalizing marijuana in some form. Four states Oregon, Washington, Colorado and Alaska have opted to legalize the drug for recreational and medical use. An additional 17 states have approved legislation regarding “CBD-only” marijuana, a chemical compound of the plant that has a wide range of medical benefits. Rosenberg said that people should not conflate recreational marijuana legalization with medical marijuana. “There are pieces of marijuanaextracts or constituents or component partsthat have great promise,” he said. “But if you talk about smoking the leaf of marijuana, which is what people are talking about when they talk about medicinal marijuana, it has never been shown to be safe or effective as a medicine.” The DEA did not respond to requests for comment from CNBC. The National Cancer Institute has not conducted its own research on marijuana’s effect on cancer symptoms and noted that there has not been substantial evidence to inhale or ingest cannabis to treat cancer-related side effects. Cannabis is also not approved by the U.S. Food and Drug Administration for use as cancer treatment or any other medical condition, according to NCI. However, some cannabinoids, the chemical compounds within the cannabis plant, have been approved for medical use.

For the original version including any supplementary images or video, visit http://www.cnbc.com/2015/11/06/dea-chief-medicinal-marijuana-is-a-joke.html

  • http://www.washingtonpost.com/blogs/right-turn/post/ding-dongs–big-labor-strikes-again/2012/11/16/e2ca4b0e-2fef-11e2-9f50-0308e1e75445_blog.html
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It Includes An Advertising Plan And Internal Polling And Blasts Marco Rubio, Who Is Also Seeking The Republican Nomination.

Wavestorms growth is odd in an industry that has traditionally used boards designed or hawked by prominent surfers and in a market that has seen slow annual growth and bankruptcies, such as Quiksilver, in recent years. [ Bloomberg ] 112 pages A 112-page internal document was leaked from Jeb Bushs presidential campaign. It includes an advertising plan and internal polling and blasts Marco Rubio, who is also seeking the Republican nomination. [ U.S. News & World Report ] 236 votes U.S. Rep. Paul Ryan of Wisconsin was elected speaker of the House, winning 236 votes from his caucus. Good luck youll need it. [ The Guardian ] 285 votes The European Parliament voted 285 to 281 in support of a resolution stating that Edward Snowden should be able to seek asylum in the European Union, a move to protect the leaker from extradition to the United States. [ Wired ] 3.7 billion The number of people younger than 50 who have the herpes simplex virus type 1, the kind that gives you cold sores around the mouth for the most part, unless you really screw up and get it on your genitals.

For the original version including any supplementary images or video, visit http://fivethirtyeight.com/datalab/significant-digits-for-friday-oct-30-2015/

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Our Design Prevents Bees And Other Pests From Nesting In Structures Around Your Home.

PITTSBURGH, PA (PRWEB) October 29, 2015 We had a pest problem when it came to bees building nests in our fence post, said one of two inventors, from Wayne, N.J. We thought there needed to be a safe and convenient solution, so we invented this. They invented the patent-pending BEE B GONE. The BEE B GONE prevents bees, wasps and hornets from building nests within a post hole or void. As a result, it could help to reduce the possibility of bee stings and it enhances safety. The invention features a practical design that is easy to install and use so it is ideal for use by homeowners. Additionally, the BEE B GONE offers added convenience and it is producible in design variations. The inventors described the invention design. Our design prevents bees and other pests from nesting in structures around your home. The original design was submitted to the Hackettstown office of InventHelp. It is currently available for licensing or sale to manufacturers or marketers. For more information, write Dept.

For the original version including any supplementary images or video, visit http://www.prweb.com/releases/InventHelp-Inventions/Bee-B-Gone/prweb13023190.htm

  • http://www.telegraph.co.uk/topics/christmas/christmas-food-and-drink/9708987/Danish-sweet-treats-for-Christmas.html
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“how Do I Get Unstuck?

“We’re in debt to scientists who’ve studied immunization and diseases.” As fond of discovery as anyone, Choldenko likes to keep secrets. “Don’t tell, because it will ruin the surprise, but here’s what I’ll do in my presentation …” Agreeing to have published all but the juiciest details, Choldenko says she’ll begin with a brief PowerPoint giving the history and “more hair-raising part” of her new book. Then is a game involving a vote, a skit to make up a fake disease, a debate between two doctors offering different cures, and audience participation in developing a list of side effects. Development and programs director Sarah Blumenfeld says drawing demonstrations, in addition to readings, will be offered. Books for sale and signings by the authors allow an opportunity for children to interact directly with the artists. Choldenko says that among the frequently asked questions from writers of all ages is a question about writer’s block. “How do I get unstuck? By going to work everyday.” Beyond that, Choldenko says if the words are not coming easily, she often needs more information. It might be more research on a person or place, or it might be she needs to push back from the page and allow herself to generate a new angle on a subject.

For the original version including any supplementary images or video, visit http://www.contracostatimes.com/lafayette/ci_29008330/lafayette-holds-childrens-book-festival

Jimmy Hurt His Hand When He Killed Paul.

Lufthansa heist While Vitale offered a compelling look Monday into the rules and hierarchy of organized crime, it was Valenti’s testimony Tuesday that ties Asaro to the most serious charges he is facing, including what prosecutors call the “score of all scores” — the Lufthansa heist. In that robbery, a band of robbers stole about $5 million in cash and nearly $1 million in jewels from an airline cargo building in the largest cash robbery in the nation’s history at the time. Asaro was one of five reputed mobsters indicted in January for the long-unsolved crime. Valenti testified that Asaro invited him to take part in the heist, and on the night of the robbery, cautioned him to “make sure you do everything you’re supposed to do. Don’t dog it. If anything happens, stand your ground, do the robbery the best you can.” While Asaro waited outside the terminal in a decoy “crash car” which would intercept the police in case they responded to the heist, Valenti testified that the robbery team, brandishing guns, detained Lufthansa terminal workers and robbed the vault of 50 boxes — each containing $125,000; a silver box of jewelry and German money. Valenti recalled being “happy” and “euphoric” after the group realized the size of its score. Dealing with ‘a rat’ In grim testimony that gave a glimpse into how the mob deals with those who cooperate with law enforcement, Valenti also recalled when Asaro and his partner Jimmy Burke buried the body of a warehouse owner whom they accused of being a “rat.” Paul Katz disappeared in 1969. Asaro allegedly told Valenti that he “did most of the digging. Jimmy hurt his hand when he killed Paul. They strangled him with a dog chain.” The body was buried at a vacant house owned by Asaro and covered up with cement, according to Valenti’s testimony.

For the original version including any supplementary images or video, visit http://www.news8000.com/news/trial-breaks-organized-crimes-code-of-silence/35976740

Well, It Turns Out The Long-held Conventional Wisdom About The Naked Mole-rat Being Inbred Is Wrong, According To A University Of Virginia-led Study Published Recently In The Journal Molecular Ecology.

From a natural selection standpoint — where advantageous traits are passed down to succeeding generations — what is gained by limiting genetic diversity by limiting the breeding pool? Evolutionary biologists have puzzled over and debated this for decades. For this reason, the naked mole-rat has been an interesting oddball study model. Well, it turns out the long-held conventional wisdom about the naked mole-rat being inbred is wrong, according to a University of Virginia-led study published recently in the journal Molecular Ecology. UVA biologist Colleen Ingram and a team of researchers from several U.S. universities and the American Museum of Natural History conducted genetics studies of different mole-rat populations from Africa, and compared them to the genetics of a long-studied mole-rat population. They found that the populations of mole-rats studied for decades are “inbred” only because they originally came from a small, genetically isolated population of naked mole-rats from south of Kenya’s Athi River. The researchers discovered that larger wild populations from north of that river and from the Tana River region are genetically variable, like other mammals — meaning they are not inbred, despite their unusual eusocial mating behavior. “We now know, from looking at the big picture from a much larger geographic area than previously studied, that the naked mole-rat is not inbred at all,” Ingram said. “What we thought we knew was based on early genetics studies of a small inbred sample from an otherwise genetically variable species.

For the original version including any supplementary images or video, visit http://www.sciencedaily.com/releases/2015/10/151022141702.htm